Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain.
Identifieur interne : 000324 ( Main/Exploration ); précédent : 000323; suivant : 000325Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain.
Auteurs : Juan Ledesma [Espagne] ; Francisco Pozo ; Gabriel Reina ; Miriam Blasco ; Guadalupe Rodríguez ; Milagrosa Montes ; Isabel L Pez-Miragaya ; Carmen Salvador ; Jordi Reina ; Raúl Ortíz De Lejarazu ; Pilar Egido ; José L Pez Barba ; Concepci N Delgado ; María Teresa Cuevas ; Inmaculada CasasSource :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2012.
Descripteurs français
- KwdFr :
- Espagne (épidémiologie), Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Grippe humaine (virologie), Grippe humaine (épidémiologie), Gènes viraux (MeSH), Humains (MeSH), Phylogenèse (MeSH), Proline (métabolisme), Saisons (MeSH), Sous-type H1N1 du virus de la grippe A (classification), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (métabolisme), Sous-type H1N1 du virus de la grippe A (pathogénicité), Substitution d'acide aminé (MeSH), Variation des antigènes (MeSH), Variation génétique (MeSH).
- MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H1N1 du virus de la grippe A.
- métabolisme : Glycoprotéine hémagglutinine du virus influenza, Proline, Sous-type H1N1 du virus de la grippe A.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Espagne, Grippe humaine.
- Gènes viraux, Humains, Phylogenèse, Saisons, Substitution d'acide aminé, Variation des antigènes, Variation génétique.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Amino Acid Substitution (MeSH), Antigenic Variation (MeSH), Genes, Viral (MeSH), Genetic Variation (MeSH), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans (MeSH), Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (metabolism), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza, Human (epidemiology), Influenza, Human (virology), Phylogeny (MeSH), Proline (metabolism), Seasons (MeSH), Spain (epidemiology).
- MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, Proline.
- geographic , epidemiology : Spain.
- classification : Influenza A Virus, H1N1 Subtype.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- metabolism : Influenza A Virus, H1N1 Subtype.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Amino Acid Substitution, Antigenic Variation, Genes, Viral, Genetic Variation, Humans, Phylogeny, Seasons.
Abstract
BACKGROUND
Genetic diversity of influenza A(H1N1)2009 viruses has been reported since the pandemic virus emerged in April 2009. Different genetic clades have been identified and defined based on amino acid substitutions found in the haemagglutinin (HA) protein sequences. In Spain, circulating influenza viruses are monitored each season by the regional laboratories enrolled in the Spanish Influenza Surveillance System (SISS). The analysis of the HA gene sequence helps to detect the genetic diversity and viral evolution.
OBJECTIVES
To perform an analysis of the genetic diversity of influenza A(H1N1)2009 viruses circulating in Spain during the season 2010-2011 based on analysis of the HA sequence gene.
STUDY DESIGN
Phylogenetic analysis based on the HA1 subunit of the haemagglutinin gene was carried out on 220 influenza A(H1N1)2009 viruses circulating during the season 2010-2011.
RESULTS
Six different genetic groups were identified among circulating A(H1N1)2009 viruses, five of them were previously reported during season 2010-2011. A new group, characterized by E172K and K308E changes and a proline at position 83, was observed in 12.27% of the Spanish viruses.
CONCLUSION
Co-circulation of six different genetic groups of influenza A(H1N1)2009 viruses was identified in Spain during the season 2010-2011. Nevertheless, at this stage, none of the groups identified to date have resulted in significant antigenic changes according to data collected by World Health Organization Collaborating Centres for influenza surveillance.
DOI: 10.1016/j.jcv.2011.09.032
PubMed: 22071031
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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(épidémiologie)</term><term>Gènes viraux (MeSH)</term><term>Humains (MeSH)</term><term>Phylogenèse (MeSH)</term><term>Proline (métabolisme)</term><term>Saisons (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (classification)</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (métabolisme)</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term><term>Substitution d'acide aminé (MeSH)</term><term>Variation des antigènes (MeSH)</term><term>Variation génétique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Proline</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Proline</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Substitution</term><term>Antigenic Variation</term><term>Genes, Viral</term><term>Genetic Variation</term><term>Humans</term><term>Phylogeny</term><term>Seasons</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Gènes viraux</term><term>Humains</term><term>Phylogenèse</term><term>Saisons</term><term>Substitution d'acide aminé</term><term>Variation des antigènes</term><term>Variation génétique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Genetic diversity of influenza A(H1N1)2009 viruses has been reported since the pandemic virus emerged in April 2009. Different genetic clades have been identified and defined based on amino acid substitutions found in the haemagglutinin (HA) protein sequences. In Spain, circulating influenza viruses are monitored each season by the regional laboratories enrolled in the Spanish Influenza Surveillance System (SISS). The analysis of the HA gene sequence helps to detect the genetic diversity and viral evolution.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To perform an analysis of the genetic diversity of influenza A(H1N1)2009 viruses circulating in Spain during the season 2010-2011 based on analysis of the HA sequence gene.</p></div><div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b></p><p>Phylogenetic analysis based on the HA1 subunit of the haemagglutinin gene was carried out on 220 influenza A(H1N1)2009 viruses circulating during the season 2010-2011.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Six different genetic groups were identified among circulating A(H1N1)2009 viruses, five of them were previously reported during season 2010-2011. A new group, characterized by E172K and K308E changes and a proline at position 83, was observed in 12.27% of the Spanish viruses.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Co-circulation of six different genetic groups of influenza A(H1N1)2009 viruses was identified in Spain during the season 2010-2011. Nevertheless, at this stage, none of the groups identified to date have resulted in significant antigenic changes according to data collected by World Health Organization Collaborating Centres for influenza surveillance.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22071031</PMID><DateCompleted><Year>2012</Year><Month>03</Month><Day>26</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5967</ISSN><JournalIssue CitedMedium="Internet"><Volume>53</Volume><Issue>1</Issue><PubDate><Year>2012</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title><ISOAbbreviation>J. Clin. Virol.</ISOAbbreviation></Journal><ArticleTitle>Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain.</ArticleTitle><Pagination><MedlinePgn>16-21</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcv.2011.09.032</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Genetic diversity of influenza A(H1N1)2009 viruses has been reported since the pandemic virus emerged in April 2009. Different genetic clades have been identified and defined based on amino acid substitutions found in the haemagglutinin (HA) protein sequences. In Spain, circulating influenza viruses are monitored each season by the regional laboratories enrolled in the Spanish Influenza Surveillance System (SISS). The analysis of the HA gene sequence helps to detect the genetic diversity and viral evolution.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To perform an analysis of the genetic diversity of influenza A(H1N1)2009 viruses circulating in Spain during the season 2010-2011 based on analysis of the HA sequence gene.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Phylogenetic analysis based on the HA1 subunit of the haemagglutinin gene was carried out on 220 influenza A(H1N1)2009 viruses circulating during the season 2010-2011.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Six different genetic groups were identified among circulating A(H1N1)2009 viruses, five of them were previously reported during season 2010-2011. A new group, characterized by E172K and K308E changes and a proline at position 83, was observed in 12.27% of the Spanish viruses.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Co-circulation of six different genetic groups of influenza A(H1N1)2009 viruses was identified in Spain during the season 2010-2011. Nevertheless, at this stage, none of the groups identified to date have resulted in significant antigenic changes according to data collected by World Health Organization Collaborating Centres for influenza surveillance.</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ledesma</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>National Influenza Centre-Madrid, Influenza and Respiratory Viruses Laboratory, Instituto de Salud Carlos III, Madrid, Spain. jledesmam@isciii.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pozo</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Reina</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Blasco</LastName><ForeName>Miriam</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Guadalupe</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Montes</LastName><ForeName>Milagrosa</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>López-Miragaya</LastName><ForeName>Isabel</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Salvador</LastName><ForeName>Carmen</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Reina</LastName><ForeName>Jordi</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ortíz de Lejarazu</LastName><ForeName>Raúl</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Egido</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>López Barba</LastName><ForeName>José</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Delgado</LastName><ForeName>Concepción</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Cuevas</LastName><ForeName>María Teresa</ForeName><Initials>MT</Initials></Author><Author ValidYN="Y"><LastName>Casas</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><CollectiveName>Spanish Influenza Surveillance System (SISS)</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>11</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Clin Virol</MedlineTA><NlmUniqueID>9815671</NlmUniqueID><ISSNLinking>1386-6532</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>9DLQ4CIU6V</RegistryNumber><NameOfSubstance UI="D011392">Proline</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019943" MajorTopicYN="N">Amino Acid Substitution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000940" MajorTopicYN="N">Antigenic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005814" MajorTopicYN="N">Genes, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011392" MajorTopicYN="N">Proline</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><InvestigatorList><Investigator ValidYN="Y"><LastName>Casas</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pozo</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ledesma</LastName><ForeName>Juan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cuevas</LastName><ForeName>María Teresa</ForeName><Initials>MT</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Lejarazu</LastName><ForeName>Raúl Ortiz</ForeName><Initials>RO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Eiros</LastName><ForeName>José María</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pumarola</LastName><ForeName>Tomás</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marcos</LastName><ForeName>María Angeles</ForeName><Initials>MA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Navarro</LastName><ForeName>José María</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez Ruiz</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Omeñaca</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Egido</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Oña</LastName><ForeName>María</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Melón</LastName><ForeName>Santiago</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Reina</LastName><ForeName>Jordi</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez</LastName><ForeName>Carmen</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sanjuán</LastName><ForeName>María Victoria</ForeName><Initials>MV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gimeno</LastName><ForeName>Concepción</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Teno Sánchez</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Guadalupe</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Galán</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Reina</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez-Trallero</LastName><ForeName>Emilio</ForeName><Initials>E</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Slavador</LastName><ForeName>Carmen</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Navarro Madrid</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mayoral</LastName><ForeName>Jose María</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez de Ágreda</LastName><ForeName>Juan Pablo Alonso</ForeName><Initials>JP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Margolles Martins</LastName><ForeName>Mario</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Riutort</LastName><ForeName>Antonio Nicolau</ForeName><Initials>AN</Initials></Investigator><Investigator ValidYN="Y"><LastName>González</LastName><ForeName>Lucas</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Viloria</LastName><ForeName>Luis 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ValidYN="Y"><LastName>Castilla</LastName><ForeName>Jesús</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arteagoitia</LastName><ForeName>José María</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Perucha</LastName><ForeName>Milagros</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rivas</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Castrillejo</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>García</LastName><ForeName>Rocío</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Larrauri</LastName><ForeName>Amparo</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jimenez Jorge</LastName><ForeName>Silvia</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Delgado</LastName><ForeName>Concepción</ForeName><Initials>C</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>08</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>09</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>09</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22071031</ArticleId><ArticleId IdType="pii">S1386-6532(11)00416-1</ArticleId><ArticleId IdType="doi">10.1016/j.jcv.2011.09.032</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Blasco, Miriam" sort="Blasco, Miriam" uniqKey="Blasco M" first="Miriam" last="Blasco">Miriam Blasco</name><name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name><name sortKey="Cuevas, Maria Teresa" sort="Cuevas, Maria Teresa" uniqKey="Cuevas M" first="María Teresa" last="Cuevas">María Teresa Cuevas</name><name sortKey="Delgado, Concepci N" sort="Delgado, Concepci N" uniqKey="Delgado C" first="Concepci N" last="Delgado">Concepci N Delgado</name><name sortKey="Egido, Pilar" sort="Egido, Pilar" uniqKey="Egido P" first="Pilar" last="Egido">Pilar Egido</name><name sortKey="L Pez Barba, Jose" sort="L Pez Barba, Jose" uniqKey="L Pez Barba J" first="José" last="L Pez Barba">José L Pez Barba</name><name sortKey="L Pez Miragaya, Isabel" sort="L Pez Miragaya, Isabel" uniqKey="L Pez Miragaya I" first="Isabel" last="L Pez-Miragaya">Isabel L Pez-Miragaya</name><name sortKey="Montes, Milagrosa" sort="Montes, Milagrosa" uniqKey="Montes M" first="Milagrosa" last="Montes">Milagrosa Montes</name><name sortKey="Ortiz De Lejarazu, Raul" sort="Ortiz De Lejarazu, Raul" uniqKey="Ortiz De Lejarazu R" first="Raúl" last="Ortíz De Lejarazu">Raúl Ortíz De Lejarazu</name><name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name><name sortKey="Reina, Gabriel" sort="Reina, Gabriel" uniqKey="Reina G" first="Gabriel" last="Reina">Gabriel Reina</name><name sortKey="Reina, Jordi" sort="Reina, Jordi" uniqKey="Reina J" first="Jordi" last="Reina">Jordi Reina</name><name sortKey="Rodriguez, Guadalupe" sort="Rodriguez, Guadalupe" uniqKey="Rodriguez G" first="Guadalupe" last="Rodríguez">Guadalupe Rodríguez</name><name sortKey="Salvador, Carmen" sort="Salvador, Carmen" uniqKey="Salvador C" first="Carmen" last="Salvador">Carmen Salvador</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ledesma, Juan" sort="Ledesma, Juan" uniqKey="Ledesma J" first="Juan" last="Ledesma">Juan Ledesma</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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